glafenine

Term ID

CHEBI:31653

Synonyms

2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilate
4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride
4-(2'-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
Glafenin
glafenina
glafenine
glafeninum
Glaphenin
Glaphenine
Glicafan
Glifan
Glifanan
Glycerylaminophenaquine

Definition

A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.

References

Beilstein:497124
CAS:3820-67-5
Drug_Central:1297
KEGG:D01351
LINCS:LSM-4419
PMID:19567678
PMID:2210868
Patent:US3232944
Reaxys:497124
Wikipedia:Glafenine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aminoquinoline carboxylic ester glycol organochlorine compound secondary amino compound

aminoquinoline carboxylic ester glycol organochlorine compound secondary amino compound Show first 5 Terms
has_functional_parent: anthranilic acid glycerol

anthranilic acid glycerol Show first 5 Terms
has_role: inhibitor non-narcotic analgesic non-steroidal anti-inflammatory drug

inhibitor non-narcotic analgesic non-steroidal anti-inflammatory drug Show first 5 Terms

Phenotype

Phenotype resulting from glafenine

Phenotype where environments contain glafenine

Phenotype modified by environments containing glafenine

Human Disease / Model Data

Citations