febuxostat

Term ID

CHEBI:31596

Synonyms

• 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
• 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
• Adenuric
• Donifoxate
• Febuday
• Feburic
• febuxostat
• febuxostatum
• Goturic
• Goutex
• TEI 6720
• TEI-6720
• TMX 67
• TMX-67
• Uloric
• Zurig

Definition

A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.

References

• cas:144060-53-7
• drugbank:DB04854
• drugcentral:1137
• kegg.drug:D01206
• lincs.smallmolecule:LSM-3064
• pdb-ccd:TEI
• pubmed:25724536
• pubmed:30844048
• pubmed:30919894
• pubmed:31267805
• pubmed:31332638
• pubmed:31335677
• pubmed:31378626
• pubmed:31447893
• pubmed:31449565
• pubmed:31499267
• pubmed:31531831
• pubmed:31560952
• wikipedia.en:Febuxostat

Ontology

ChEBI  ( EBI )