Search Ontology:
ChEBI
epalrestat
- Term ID
- CHEBI:31539
- Synonyms
-
- 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- epalrestat
- Definition
- A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
- References
-
- CAS:82159-09-9
- Drug_Central:1021
- KEGG:D01688
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from epalrestat
Phenotype where environments contain epalrestat
Phenotype modified by environments containing epalrestat
Phenotype affecting epalrestat
Human Disease Model