bicuculline

Term ID

CHEBI:3092

Synonyms

• (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
• Bicculine
• Bicucullin
• Bicuculline
• d-Bicuculline

Definition

A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.

References

• Beilstein:98786
• CAS:485-49-4
• KEGG:C09364
• KNApSAcK:C00001820
• PMID:27579770
• PMID:29137474
• PMID:29949743
• PMID:30858801
• Wikipedia:Bicuculline

Ontology

ChEBI  ( EBI )

Resources

CTD