thiostrepton

Term ID

CHEBI:29693

Synonyms

bryamycin
gargon
thiactin
Thiostrepton
thiostrepton A

Definition

A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.

References

cas:1393-48-2
drugbank:DB11467
kegg.compound:C12054
kegg.drug:D06111
knapsack:C00000753
metacyc.compound:CPD-13481
pubmed:14405296
pubmed:16076225
pubmed:19652535
pubmed:21107477
pubmed:21323347
pubmed:21365012
pubmed:21620902
pubmed:21860463
pubmed:21903609
pubmed:21908407
pubmed:22049175
pubmed:22108865
pubmed:22271891
pubmed:22321511
pubmed:22353937
pubmed:22357874
pubmed:22391527
pubmed:31835481
pubmed:32330398
pubmed:33193851
pubmed:33498547
pubmed:33515584
pubmed:34369229
pubmed:34863996
pubmed:35859150
pubmed:35873171
pubmed:36097108
pubmed:36152915
pubmed:36910221
pubmed:37646656
pubmed:37662481
pubmed:37752225
pubmed:38634704
pubmed:38652969
reaxys:7390758
vsdb:3007
wikipedia.en:Thiostrepton

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from thiostrepton

Phenotype where environments contain thiostrepton

Phenotype modified by environments containing thiostrepton

Phenotype affecting thiostrepton

Human Disease Model