manumycin A

Term ID

CHEBI:29623

Synonyms

(-)-manumycin A
(2E,4E,6R)-N-[(1S,5S,6R)-5-Hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-2,4-decadienamide
(2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
manumycin
manumycin A
NSC 622141
UCF 1C
UCF1-C

Definition

A polyketide with formula C₃₁H₃₈N₂O₇ initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.

References

cas:52665-74-4
chemspider:4942813
hmdb:HMDB0242678
kegg.compound:C12111
lipidmaps:LMFA08020185
metacyc.compound:CPD-18768
pmc:PMC3513075
pubmed:12699746
pubmed:15787434
pubmed:17363690
pubmed:21349982
pubmed:22272079
pubmed:23328664
pubmed:23730936
pubmed:23828222
pubmed:24899815
pubmed:25556058
pubmed:26602157
pubmed:26962870
pubmed:27176604
pubmed:27307747
pubmed:27878284
pubmed:28844715
pubmed:29670693
pubmed:30476593
pubmed:30785834
pubmed:32298799
pubmed:32344935
pubmed:33719954
pubmed:34200371
pubmed:3693123
pubmed:8460134

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from manumycin A

Phenotype where environments contain manumycin A

Phenotype modified by environments containing manumycin A

Phenotype affecting manumycin A

Human Disease Model