azathioprine

Term ID

CHEBI:2948

Synonyms

6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
Imuran (TN)

Definition

A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

References

cas:446-86-6
drugbank:DB00993
drugcentral:269
kegg.compound:C06837
kegg.drug:D00238
pubmed:11064448
pubmed:15199672
pubmed:15476481
pubmed:15628319
pubmed:15973722
pubmed:16344342
pubmed:16397313
pubmed:16764353
pubmed:16954801
pubmed:17381669
pubmed:17970886
pubmed:18008354
pubmed:18336531
pubmed:19243907
pubmed:20080917
pubmed:25248004
pubmed:25314066
pubmed:25440430
pubmed:25443086
pubmed:25581826
pubmed:25641386
pubmed:28166217
pubmed:8738760
pubmed:9273463
pubmed:9345422
reaxys:1225351
wikipedia.en:Azathioprine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from azathioprine

Phenotype where environments contain azathioprine

Phenotype modified by environments containing azathioprine

Phenotype affecting azathioprine

Human Disease Model