acadesine

Term ID

CHEBI:28498

Synonyms

5-amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide
5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide
5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide
5-amino-1-beta-ribofuranosyl-imidazole-4-carboxamide
5-amino-1-ribofuranosylimidazole-4-carboxamide
5-amino-1beta-D-ribofuranosylimidazole-4-carboxyamide
5-amino-4-imidazolecarboxamide ribofuranoside
5-aminoimidazole-4-carboxamide ribonucleoside
acadesina
acadesine
acadesinum
AIC-Riboside
AICA-riboside
AICAr
EC Number 220-097-5
GP 1-110
GP-1-110
N(1)-(beta-D-ribofuranosyl)-5-aminoimidazole-4-carboxamide

Definition

A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.

References

cas:2627-69-2
drugbank:DB04944
drugcentral:37
kegg.drug:D02742
pubmed:17513706
pubmed:17706943
pubmed:18090925
pubmed:18457469
pubmed:18671468
pubmed:20185792
pubmed:20367195
pubmed:21244913
pubmed:23228986
pubmed:24303202
pubmed:24519895
pubmed:24778186
pubmed:8227467
pubmed:8458030
reaxys:38255
wikipedia.en:Acadesine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from acadesine

Phenotype where environments contain acadesine

Phenotype modified by environments containing acadesine

Phenotype affecting acadesine

Human Disease Model