vincristine

Term ID

CHEBI:28445

Synonyms

(+)-Vincristine
22-oxo-vincaleukoblastine
22-Oxovincaleukoblastine
leucristine
leurocristine
oncovin
vincristin
Vincristine
vinkristin

Definition

A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.

References

Beilstein:4779289
CAS:57-22-7
DrugBank:DB00541
Drug_Central:2825
HMDB:HMDB0014681
KEGG:C07204
KEGG:D08679
KNApSAcK:C00001783
MetaCyc:CPD-19894
PMID:18520608
PMID:30277559
PMID:30429697
PMID:30599272
PMID:30604513
PMID:30657998
PMID:31048222
PMID:31161774
PMID:31214762
PMID:31296986
Wikipedia:Vincristine

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetate ester formamides methyl ester organic heteropentacyclic compound organic heterotetracyclic compound ... Show All 8 Terms

acetate ester formamides methyl ester organic heteropentacyclic compound organic heterotetracyclic compound tertiary alcohol tertiary amino compound vinca alkaloid Show first 5 Terms
has_parent_hydride: vincaleukoblastine

vincaleukoblastine Show first 5 Terms
has_role: antineoplastic agent drug microtubule-destabilising agent plant metabolite tubulin modulator

antineoplastic agent drug microtubule-destabilising agent plant metabolite tubulin modulator Show first 5 Terms
inverse is_conjugate_acid_of: vincristine(2+)

vincristine(2+) Show first 5 Terms
is_conjugate_base_of: vincristine(2+)

vincristine(2+) Show first 5 Terms

Phenotype

Phenotype resulting from vincristine

Phenotype where environments contain vincristine

Phenotype modified by environments containing vincristine

Human Disease / Model Data

Citations