trioxsalen

Term ID

CHEBI:28329

Synonyms

• 2',4,8-Trimethylpsoralen
• 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
• 4,5',8-Trimethylpsoralen
• 4,8,5'-Trimethylpsoralen
• 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
• Trimethylpsoralen
• trioxisaleno
• Trioxsalen
• Trioxysalen
• trioxysalene
• trioxysalenum

Definition

7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

References

• Beilstein:221723
• CAS:3902-71-4
• DrugBank:DB04571
• Drug_Central:2759
• KEGG:C09314
• KEGG:D01034
• KNApSAcK:C00002502
• LINCS:LSM-3223
• Patent:US3201421
• Wikipedia:Trioxsalen

Ontology

ChEBI  ( EBI )

Resources

CTD