aphidicolin

Term ID

CHEBI:2766

Synonyms

(3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol
Aphidicolin
aphidocolin

Definition

A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.

References

beilstein:4689958
cas:38966-21-1
chemspider:10280269
kegg.compound:C06088
knapsack:C00000873
lincs.smallmolecule:LSM-45486
metacyc.compound:CPD-11426
patent:US3761512
pdb-ccd:2ZE
pubmed:10592317
pubmed:1483268
pubmed:19735659
pubmed:21212237
pubmed:21444690
pubmed:21708134
pubmed:21812410
pubmed:21897020
pubmed:21917855
pubmed:22139884
pubmed:22210918
pubmed:22262459
pubmed:22293751
pubmed:22302683
pubmed:22339690
pubmed:22365495
pubmed:23221037
pubmed:24492257
pubmed:25429975
pubmed:25948499
pubmed:26255574
pubmed:26854444
pubmed:27223263
pubmed:27265376
pubmed:29191129
pubmed:31403790
pubmed:31448675
pubmed:31712575
pubmed:32394671
pubmed:33592314
pubmed:33721476
pubmed:7478586
reaxys:2055641
wikipedia.en:Aphidicolin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from aphidicolin

Phenotype where environments contain aphidicolin

Phenotype modified by environments containing aphidicolin

Phenotype affecting aphidicolin

Human Disease Model