angiotensin I

Term ID

CHEBI:2718

Synonyms

• angiotensin I
• Angiotonin
• Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
• D-R-V-Y-I-H-P-F-H-L
• DRVYIHPFHL
• Hypertensin
• L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
• L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-L-Leu
• pepsitensin
• proangiotensin

Definition

A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.

References

• CAS:9041-90-1
• HMDB:HMDB0061196
• KEGG:C00873
• MetaCyc:CPD-13004
• PMID:20026757
• PMID:31746507
• PMID:32028998
• PMID:32238693
• PMID:836506
• Patent:WO2009040072

Ontology

ChEBI  ( EBI )

Resources

CTD