amifostine

Term ID

CHEBI:2636

Synonyms

amifostina
Amifostine
amifostinum
Ethyol
S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate

Definition

An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.

References

cas:20537-88-6
drugbank:DB01143
drugcentral:156
hmdb:HMDB0015274
kegg.compound:C06819
lincs.smallmolecule:LSM-4721
patent:US3892824
pubmed:10553165
pubmed:10942928
pubmed:11013273
pubmed:11201306
pubmed:11984063
pubmed:12005544
pubmed:12433814
pubmed:12499421
pubmed:12561384
pubmed:12751907
pubmed:14980067
pubmed:15380592
pubmed:15698860
pubmed:15875769
pubmed:16465691
pubmed:17602063
pubmed:18072151
pubmed:18549666
pubmed:19712749
pubmed:20334641
pubmed:21347716
pubmed:21646919
pubmed:22267539
pubmed:22402174
pubmed:22440042
pubmed:22456378
pubmed:22496587
pubmed:22643562
pubmed:22844290
pubmed:22878481
pubmed:22885239
pubmed:22989457
pubmed:23040218
pubmed:23052919
pubmed:23092832
pubmed:23401928
pubmed:8612469
pubmed:8683243
reaxys:2088122
wikipedia.en:Amifostine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from amifostine

Phenotype where environments contain amifostine

Phenotype modified by environments containing amifostine

Phenotype affecting amifostine

Human Disease Model