Search Ontology:
ChEBI
edrophonium
- Term ID
- CHEBI:251408
- Synonyms
-
- (3-hydroxyphenyl)dimethylethylammonium
- 3-hydroxy-N,N-dimethyl-N-ethylanilinium
- Edrophonium
- Definition
- A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
- References
-
- Beilstein:3905622
- CAS:312-48-1
- DrugBank:DB01010
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from edrophonium
Phenotype where environments contain edrophonium
Phenotype modified by environments containing edrophonium
Phenotype affecting edrophonium
Human Disease Model