adefovir

Term ID

CHEBI:2469

Synonyms

9-(2-(Phosphonomethoxy)ethyl)adenine
9-(2-Phosphonylmethoxyethyl)adenine
Adefovir
DRG-0156
GS 0393
GS 393
GS-0393
HSDB 8079
N-(2-Phosphonylmethoxyethyl)adenine
PMEA
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid

(all 11)

Definition

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.

References

(all 32)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 6-aminopurines ether phosphonic acids

6-aminopurines ether phosphonic acids Show first 5 Terms
has_functional_parent: adenine

adenine Show first 5 Terms
has_role: antiviral drug DNA synthesis inhibitor drug metabolite HIV-1 reverse transcriptase inhibitor nephrotoxic agent

antiviral drug DNA synthesis inhibitor drug metabolite HIV-1 reverse transcriptase inhibitor nephrotoxic agent Show first 5 Terms
inverse has_functional_parent: adefovir pivoxil

adefovir pivoxil Show first 5 Terms
inverse is_conjugate_base_of: adefovir(1-)

adefovir(1-) Show first 5 Terms
is_conjugate_acid_of: adefovir(1-)

adefovir(1-) Show first 5 Terms

Phenotype

Phenotype resulting from adefovir

Phenotype where environments contain adefovir

Phenotype modified by environments containing adefovir

Phenotype affecting adefovir

Human Disease Model