dorzagliatin

Term ID

CHEBI:234514

Synonyms

• (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
• dorzagliatin
• dorzagliatina
• dorzagliatine
• dorzagliatinum
• HMS 5552
• HMS-5552
• HMS5552
• HuaTangNing

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methylpentanoic acid with the amino group of (2R)-3-(3-amino-1H-pyrrol-1-yl)propane-1,2-diol. It is an allosteric glucokinase activator developed by Hua Medicine for the treatment of type 1 and 2 diabetes mellitus , and diabetic kidney disease.

References

• cas:1191995-00-2
• drugbank:DB15123
• kegg.drug:D11342
• pmc:PMC11454996
• pubmed:29707866
• pubmed:34706161
• pubmed:35067153
• pubmed:35551292
• pubmed:35551294
• pubmed:36342518
• pubmed:36449148
• pubmed:36505359
• pubmed:36566614
• pubmed:36918550
• pubmed:37385967
• pubmed:37537410
• pubmed:37777375
• pubmed:38179187
• pubmed:38203742
• pubmed:38394489
• pubmed:38460077
• pubmed:38664885
• pubmed:38691834
• pubmed:38783768
• pubmed:39211666
• pubmed:39214626
• pubmed:39580550
• pubmed:39629068
• pubmed:39817211
• pubmed:40231509
• pubmed:40239741
• pubmed:40272935
• pubmed:40560322
• wikipedia.en:Dorzagliatin

Ontology

ChEBI  ( EBI )