Search Ontology:
ChEBI
methylthioadenosine-DADMe immucillin-A
- Term ID
- CHEBI:234322
- Synonyms
-
- (3R,4S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl)-4-methylsulfanylmethyl-pyrrolidin-3-ol
- (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol
- (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-3-pyrrolidinol
- methylthio-DADMe-immucillin A
- methylthio-DADMe-immucillin-A
- MT-DADMe-ImmA
- MT-DADMe-Immucillin-A
- MTDIA
- Definition
- A pyrrolopyrimidine that is 5H-pyrrolo[3,2-d]pyrimidin-4-amine substituted by a {(3R,4S)-3-hydroxy-4-[(methylsulfanyl)methyl]pyrrolidin-1-yl}methyl group at position 7. It is a potent inhibitor of human 5'-methylthioadenosine phosphorylase (Ki = 86 pM) with anti-tumour activity.
- References
-
- cas:653592-04-2
- drugbank:DB08606
- pdb-ccd:TDI
- pubmed:14705926
- pubmed:15746096
- pubmed:15749708
- pubmed:17059210
- pubmed:17548352
- pubmed:18776260
- pubmed:19270684
- pubmed:21135097
- pubmed:21675920
- pubmed:22854195
- pubmed:24148083
- pubmed:24502544
- pubmed:25387827
- pubmed:26260335
- pubmed:28026167
- pubmed:32022543
- pubmed:33893330
- pubmed:36920074
- pubmed:37301365
- pubmed:38000655
- pubmed:40375736
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from methylthioadenosine-DADMe immucillin-A
Phenotype where environments contain methylthioadenosine-DADMe immucillin-A
Phenotype modified by environments containing methylthioadenosine-DADMe immucillin-A
Phenotype affecting methylthioadenosine-DADMe immucillin-A
Human Disease Model