UNC0642

Term ID

CHEBI:233643

Synonyms

2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
UNC 0642
UNC-0642

Definition

A member of the class of quinazolines that is quinazoline substituted by 4,4-difluoropiperidin-1-yl, [1-(propan-2-yl)piperidin-4-yl]amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a potent inhibitor of histone methyltransferases G9a and GLP (IC50 = <2.5 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopiperidine aromatic ether organofluorine compound pyrrolidines quinazolines ... Show All 7 Terms

aminopiperidine aromatic ether organofluorine compound pyrrolidines quinazolines secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer

antineoplastic agent apoptosis inducer Show first 5 Terms

Phenotype

Phenotype resulting from UNC0642

Phenotype where environments contain UNC0642

Phenotype modified by environments containing UNC0642

Phenotype affecting UNC0642

Human Disease Model