UNC0642

Term ID

CHEBI:233643

Synonyms

• 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
• 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
• UNC 0642
• UNC-0642

Definition

A member of the class of quinazolines that is quinazoline substituted by 4,4-difluoropiperidin-1-yl, [1-(propan-2-yl)piperidin-4-yl]amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a potent inhibitor of histone methyltransferases G9a and GLP (IC₅₀ = <2.5 nM).

References

• cas:1481677-78-4
• hmdb:HMDB0259403
• pubmed:24102134
• pubmed:30730848
• pubmed:30765842
• pubmed:33632299
• pubmed:34307805
• pubmed:34344448
• pubmed:37748637
• pubmed:38216073
• pubmed:39018829

Ontology

ChEBI  ( EBI )