Search Ontology:
ChEBI
flumatinib
- Term ID
- CHEBI:233593
- Synonyms
-
- 4-[(4-methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)-benzamide
- 4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide
- flumbatinib
- flumbatinibum
- HH-GV-678
- HH-GV678
- HHGV 678
- HHGV678
- Definition
- A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 2-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]pyridine-3,5-diamine. It is an inhibitor of the non-receptor tyrosine kinase Bcr-Abl (IC50 = 1.2 nM) and has been approved in China for the treatment of chronic myeloid leukaemia.
- References
-
- CAS:895519-90-1
- Chemspider:25069687
- DrugBank:DB11904
- PMCID:PMC10428240
- PMCID:PMC9429059
- PMID:20703259
- PMID:32757049
- PMID:32797767
- PMID:36164408
- PMID:36619491
- PMID:36814813
- PMID:37006972
- PMID:37138411
- PMID:37214433
- PMID:37214442
- PMID:37551470
- PMID:38049316
- PMID:38387893
- PMID:38443260
- PMID:38461040
- PMID:38660838
- PMID:38692191
- PMID:38934064
- PMID:38992279
- PMID:39046364
- PMID:39134501
- PMID:39145083
- PMID:39296080
- PMID:39323606
- PMID:39735596
- PMID:39743250
- PMID:39816491
- PMID:39818454
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 7 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from flumatinib
Phenotype where environments contain flumatinib
Phenotype modified by environments containing flumatinib
Phenotype affecting flumatinib
Human Disease Model