suzetrigine

Term ID

CHEBI:233446

Synonyms

4-({[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-yl]carbonyl}amino)pyridine-2-carboxamide
4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine-2-carboxamide
JOURNAVX
suzetrigina
suzetrigine
suzetriginum
VX 548
VX-548
VX548

Definition

A member of the class of oxolanes that is oxolane substituted by 4-aminoacyl-pyridine-2-carboxamide, 3,4-difluoro-2-methoxyphenyl, methyl, and trifluoromethyl groups at positions 2, 3, 4, 5, and 5, respectively (the 2R,3S,4S,5R-stereoisomer). It is a selective blocker of the NaV 1.8 voltage-gated sodium channel and has been approved for the treatment of moderate to severe acute pain in adults.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: difluorobenzene monomethoxybenzene oxolanes primary carboxamide pyridinecarboxamide ... Show All 6 Terms

difluorobenzene monomethoxybenzene oxolanes primary carboxamide pyridinecarboxamide secondary carboxamide Show first 5 Terms
has_role: non-narcotic analgesic voltage-gated sodium channel blocker

non-narcotic analgesic voltage-gated sodium channel blocker Show first 5 Terms

Phenotype

Phenotype resulting from suzetrigine

Phenotype where environments contain suzetrigine

Phenotype modified by environments containing suzetrigine

Phenotype affecting suzetrigine

Human Disease Model