Search Ontology:
ChEBI
suzetrigine
- Term ID
- CHEBI:233446
- Synonyms
-
- 4-({[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-yl]carbonyl}amino)pyridine-2-carboxamide
- 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine-2-carboxamide
- JOURNAVX
- suzetrigina
- suzetrigine
- suzetriginum
- VX 548
- VX-548
- VX548
- Definition
- A member of the class of oxolanes that is oxolane substituted by 4-aminoacyl-pyridine-2-carboxamide, 3,4-difluoro-2-methoxyphenyl, methyl, and trifluoromethyl groups at positions 2, 3, 4, 5, and 5, respectively (the 2R,3S,4S,5R-stereoisomer). It is a selective blocker of the NaV 1.8 voltage-gated sodium channel and has been approved for the treatment of moderate to severe acute pain in adults.
- References
-
- cas:2649467-58-1
- drugbank:DB18927
- kegg.drug:D12860
- patent:WO2021113627
- pubmed:37530822
- pubmed:38573807
- pubmed:38783548
- pubmed:38963514
- pubmed:39322410
- pubmed:39418835
- pubmed:39552600
- pubmed:39560856
- pubmed:39775738
- wikipedia.en:Suzetrigine
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from suzetrigine
Phenotype where environments contain suzetrigine
Phenotype modified by environments containing suzetrigine
Phenotype affecting suzetrigine
Human Disease Model