zipalertinib

Term ID

CHEBI:233402

Synonyms

• (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido(5,4-b)indolizin-8-yl)acrylamide
• CLN 081
• CLN-081
• CLN081
• N-[(8S)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide
• TAS 6417
• TAS-6417
• TAS6417
• TPC 064
• TPC-064
• TPC064
• zipalertinib
• zipalertinibum

Definition

A member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations.

References

• cas:1661854-97-2
• drugbank:DB18763
• pdb-ccd:X9H
• pubmed:29748209
• pubmed:31467113
• pubmed:36324498
• pubmed:36380577
• pubmed:36915628
• pubmed:37384848
• pubmed:37487151
• pubmed:37669428
• pubmed:38229766
• pubmed:38770784
• pubmed:39417568
• pubmed:39471218
• wikipedia.en:Zipalertinib

Ontology

ChEBI  ( EBI )