tirbanibulin

Term ID

CHEBI:231702

Synonyms

5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide
Klisyri
KX 01
KX-01
KX-2-391
KX-2391
KX01
KX2-391
N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
N-benzyl-2-(5-{4-[2-(morpholin-4-yl)ethoxy]phenyl}pyridin-2-yl)acetamide
N-benzyl-5-(4-(2-morpholinoethoxy)phenyl)picolinamide
tirbanibulin
tirbanibulin free base
tirbanibulina
tirbanibuline
tirbanibulinum

Definition

A member of the class of pyridines that is pyridine substituted by 2-(benzylamino)-2-oxoethyl and 4-[2-(morpholin-4-yl)ethoxy]phenyl groups at positions 2 and 5, respectively. It is a dual inhibitor of Src kinase and tubulin and approved by the FDA for the topical treatment of actinic keratosis on the face or scalp.

References

cas:897016-82-9
drugbank:DB06137
hmdb:HMDB0304857
kegg.drug:D11691
pdb-ccd:DN0
pubmed:27737538
pubmed:33355728
pubmed:34349652
pubmed:35249711
pubmed:35579731
pubmed:35669422
pubmed:36297594
pubmed:36415541
pubmed:36699198
pubmed:37427812
pubmed:37566741
pubmed:37650424
pubmed:37758501
pubmed:37876333
pubmed:38077981
pubmed:38127321
pubmed:38139813
pubmed:38305473
pubmed:38399512
pubmed:38528791
pubmed:38605473
pubmed:38709702
pubmed:38740726
pubmed:38847867
pubmed:38851311
pubmed:38924858
pubmed:38967656
pubmed:39123274
pubmed:39133636
pubmed:39166850
wikipedia.en:Tirbanibulin

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from tirbanibulin

Phenotype where environments contain tirbanibulin

Phenotype modified by environments containing tirbanibulin

Phenotype affecting tirbanibulin

Human Disease Model