Search Ontology:
ChEBI

evofosfamide

Term ID
CHEBI:231678
Synonyms
  • (1-methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
  • 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
  • evofosfamida
  • evofosfamide
  • evofosfamidum
  • HAP-302
  • TH 302
  • TH-302
  • TH302
Definition
A member of the class of imidazoles that is 1H-imidazole substituted by methyl, nitro, and ({bis[(2-bromoethyl)amino]phosphoryl}oxy)methyl groups at positions 1, 2 and 5, respectively. It is a hypoxia-activated prodrug that targets hypoxic regions of tumors. The drug was being evaluated for first-line treatment of advanced pancreatic adenocarcinoma and advanced soft tissue sarcoma, in combination with chemotherapy (phase 3 trial now discontinued since the drug did not meet primary endpoints).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from evofosfamide
Phenotype where environments contain evofosfamide
Phenotype modified by environments containing evofosfamide
Human Disease Model
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