sulfopin

Term ID

CHEBI:231413

Synonyms

2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide
2-chloro-N-(2,2-dimethylpropyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
2-chloro-N-(2,2-dimethylpropyl)-N-(1,1-dioxo-1lambda(6)-thiolan-3-yl)acetamide
PIN1-3

Definition

A sulfone that is thiolane substituted by two oxo groups at position 1 and by a (chloroacetyl)(2,2-dimethylpropyl)amino group at position 3. It is a covalent inhibitor of Pin1 (Ki = 17 nM) that inhibits Myc-driven tumors in vivo.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: organochlorine compound sulfone tertiary carboxamide tetrahydrothiophenes

organochlorine compound sulfone tertiary carboxamide tetrahydrothiophenes Show first 5 Terms
has_role: antineoplastic agent EC 5.2.* (cis-trans-isomerase) inhibitor

antineoplastic agent EC 5.2.* (cis-trans-isomerase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from sulfopin

Phenotype where environments contain sulfopin

Phenotype modified by environments containing sulfopin

Human Disease / Model Data

Citations