TAK-733

Term ID

CHEBI:231366

Synonyms

• (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
• 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
• 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodo-phenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7-dione
• TAK 733
• TAK733

Definition

A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione substituted by (2R)-2,3-dihydroxypropyl, (2-fluoro-4-iodophenyl)amino, fluoro, and methyl groups at positions 3, 5, 6, and 8, respectively. It is a non-ATP competitive allosteric inhibitor of MEK1/2.

References

• cas:1035555-63-5
• drugbank:DB12241
• pdb-ccd:IZG
• pubmed:21310613
• pubmed:22515704
• pubmed:25376610
• pubmed:26014721
• pubmed:26439693
• pubmed:26918363
• pubmed:27650277
• pubmed:28258008
• pubmed:29674718
• pubmed:30396931
• pubmed:30714951
• pubmed:33327491
• pubmed:34534577
• pubmed:35269397
• pubmed:38027011

Ontology

ChEBI  ( EBI )