TAK-733

Term ID

CHEBI:231366

Synonyms

(R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodo-phenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7-dione
TAK 733
TAK733

Definition

A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione substituted by (2R)-2,3-dihydroxypropyl, (2-fluoro-4-iodophenyl)amino, fluoro, and methyl groups at positions 3, 5, 6, and 8, respectively. It is a non-ATP competitive allosteric inhibitor of MEK1/2.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: diol monofluorobenzenes organoiodine compound primary alcohol pyridopyrimidine ... Show All 8 Terms

diol monofluorobenzenes organoiodine compound primary alcohol pyridopyrimidine secondary alcohol secondary amino compound substituted aniline Show first 5 Terms
has_role: anti-inflammatory agent antineoplastic agent apoptosis inducer EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor

anti-inflammatory agent antineoplastic agent apoptosis inducer EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from TAK-733

Phenotype where environments contain TAK-733

Phenotype modified by environments containing TAK-733

Human Disease Model