pacritinib

Term ID

CHEBI:231350

Synonyms

(16E)-11-[2-(1-pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
(16E)-11-[2-(pyrrolidin-1-yl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(27),3,5,8(26),9,11,16,21,23-decaene
pacritinib
pacritinibum
SB 1518
SB-1518
SB1518

Definition

An azamacrocycle with formula C₂₈H₃₂N₄O₃. It is a Janus kinase inhibitor and its citrate salt is approved for the treatment of intermediate or high risk, primary or secondary myelofibrosis.

References

cas:937272-79-2
drugbank:DB11697
kegg.drug:D11768
pdb-ccd:6T3
pubmed:21604762
pubmed:25170285
pubmed:27598824
pubmed:29191878
pubmed:34551507
pubmed:35489775
pubmed:35567653
pubmed:35622972
pubmed:35877951
pubmed:35983661
pubmed:35993369
pubmed:36467816
pubmed:36469321
pubmed:36601980
pubmed:36651066
pubmed:36697489
pubmed:36822800
pubmed:36861402
pubmed:36922391
pubmed:36959157
pubmed:37203407
pubmed:37427653
pubmed:37552106
pubmed:37916436
pubmed:38164985
pubmed:38201581
pubmed:38295318
pubmed:38374336
pubmed:38562076
pubmed:38646919
wikipedia.en:Pacritinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from pacritinib

Phenotype where environments contain pacritinib

Phenotype modified by environments containing pacritinib

Phenotype affecting pacritinib

Human Disease Model