pacritinib

Term ID

CHEBI:231350

Synonyms

(16E)-11-[2-(1-pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
(16E)-11-[2-(pyrrolidin-1-yl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(27),3,5,8(26),9,11,16,21,23-decaene
pacritinib
pacritinibum
SB 1518
SB-1518
SB1518

(all 7)

Definition

An azamacrocycle with formula C28H32N4O3. It is a Janus kinase inhibitor and its citrate salt is approved for the treatment of intermediate or high risk, primary or secondary myelofibrosis.

References

(all 35)

Ontology

ChEBI ( EBI )

Relationships

is a type of: azamacrocycle benzenes cyclic ether pyrrolidines

azamacrocycle benzenes cyclic ether pyrrolidines Show first 5 Terms
has_role: anti-inflammatory agent antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor

anti-inflammatory agent antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: pacritinib(1+)

pacritinib(1+) Show first 5 Terms
is_conjugate_base_of: pacritinib(1+)

pacritinib(1+) Show first 5 Terms

Phenotype

Phenotype resulting from pacritinib

Phenotype where environments contain pacritinib

Phenotype modified by environments containing pacritinib

Phenotype affecting pacritinib

Human Disease Model