triapine

Term ID

CHEBI:231347

Synonyms

2-[(3-amino-2-pyridinyl)methylene]-hydrazinecarbothioamide
2-[(3-amino-2-pyridinyl)methylene]hydrazinecarbothioamide
2-[(3-aminopyridin-2-yl)methylidene]hydrazine-1-carbothioamide
2-[(3-aminopyridin-2-yl)methylidene]hydrazinecarbothioamide
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
3-AP
3AP
[(3-aminopyridin-2-yl)methylideneamino]thiourea
OCX 0191
OCX 191
OCX-0191
PAN 811
PAN-811
PAN811

Definition

A thiosemicarbazone resulting from the formal condensation of the formyl group of 3-aminopicolinaldehyde with the non-thioacylated amino group of hydrazinecarbothioamide. It is a ribonucleotide reductase inhibitor that exhibits anti-cancer properties.

References

cas:143621-35-6
drugbank:DB11940
pubmed:1433178
pubmed:16084648
pubmed:16443509
pubmed:16675588
pubmed:16834759
pubmed:18278438
pubmed:19637923
pubmed:20066211
pubmed:20127092
pubmed:20145183
pubmed:20440618
pubmed:21373381
pubmed:21955844
pubmed:22105720
pubmed:22335579
pubmed:23603372
pubmed:26640619
pubmed:28881312
pubmed:29370277
pubmed:30519356
pubmed:32961653
pubmed:32989483
pubmed:33185224
pubmed:34516127
pubmed:35262697
pubmed:36802558
pubmed:36925025
pubmed:37482342
pubmed:37565554
pubmed:37952032
reaxys:5811939
wikipedia.en:3-Aminopyridine-2-carboxaldehyde_thiosemicarbazone

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from triapine

Phenotype where environments contain triapine

Phenotype modified by environments containing triapine

Phenotype affecting triapine

Human Disease Model