talazoparib

Term ID

CHEBI:231344

Synonyms

BMN 673
BMN-673
BMN673
LT-673
PF-06944076
Talazoparib

Definition

Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.

References

cas:1207456-01-6
pubmed:25761096
pubmed:26652717
pubmed:27353531
pubmed:27416328
pubmed:28692916
pubmed:30684797
pubmed:31042381
pubmed:33120078
pubmed:33264017
pubmed:33691794
pubmed:34570508
pubmed:35051747
pubmed:35442700
pubmed:36989813
pubmed:37484567
pubmed:37567056
pubmed:37605459
pubmed:37843892
pubmed:38194775
pubmed:38477575
pubmed:38516606
pubmed:38776379
pubmed:38838546
pubmed:38911148

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from talazoparib

Phenotype where environments contain talazoparib

Phenotype modified by environments containing talazoparib

Phenotype affecting talazoparib

Human Disease Model