Search Ontology:
ChEBI
THZ1
- Term ID
- CHEBI:230500
- Synonyms
-
- (E)-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
- N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzamide
- THZ 1
- THZ-1
- Definition
- A member of the class of indoles that is 1H-indole substituted by a 5-chloro-2-[3-(4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzamido)anilino]pyrimidin-4-yl group at position 3. It is a selective and potent covalent inhibitor of CDK7 that exhibits anti-proliferative effects in cancer cell lines.
- References
-
- CAS:1604810-83-4
- PMID:26115571
- PMID:37147730
- PMID:37369156
- PMID:37536559
- PMID:38037549
- PMID:38293462
- PMID:38646672
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from THZ1
Phenotype where environments contain THZ1
Phenotype modified by environments containing THZ1
Human Disease / Model Data