LDN-212854

Term ID

CHEBI:229962

Synonyms

5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
5-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline
LDN 212854
LDN212854

Definition

A member of the class of quinolines that is quinoline substituted by a 6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl group at position 5. It is a potent ALK inhibitor (IC50 values of 2.4, 1.3, 85.8, 2,133 and 9,276 nM for ALK1, ALK2, ALK3, ALK4 and ALK5, respectively).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: N-arylpiperazine pyrazolopyrimidine quinolines

N-arylpiperazine pyrazolopyrimidine quinolines Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor

angiogenesis inhibitor antineoplastic agent EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from LDN-212854

Phenotype where environments contain LDN-212854

Phenotype modified by environments containing LDN-212854

Human Disease / Model Data

Citations