WZB-117

Term ID

CHEBI:229781

Synonyms

3-fluoro-1,2-phenylene bis(3-hydroxybenzoate)
3-fluorobenzene-1,2-diyl bis(3-hydroxybenzoate)
3-hydroxy-benzoic acid 1,1'-(3-fluoro-1,2-phenylene) ester
WZB 117
WZB117

Definition

A diester resulting from the formal condensation of the two hydroxy groups of 3-fluorocatechol with the carboxy groups of 3-hydroxybenzoic acid. It is an inhibitor of glucose transporter 1 (GLUT1) that suppresses tumour growth in mouse xenograft models.

References

cas:1223397-11-2
drugbank:DB16764
pubmed:25227787
pubmed:27011212
pubmed:27836974
pubmed:28609310
pubmed:29857184
pubmed:29949049
pubmed:29953861
pubmed:30918522
pubmed:31780937
pubmed:32789453
pubmed:33539362
pubmed:35754487
pubmed:36076906
pubmed:36188586
pubmed:36849757
pubmed:36850263
pubmed:37097498
pubmed:37549570
pubmed:37848084
pubmed:37944848
pubmed:38033124
pubmed:38225684

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from WZB-117

Phenotype where environments contain WZB-117

Phenotype modified by environments containing WZB-117

Phenotype affecting WZB-117

Human Disease Model