Search Ontology:
ChEBI
eltanexor
- Term ID
- CHEBI:229762
- Synonyms
-
- (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
- (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-triazol-1-yl)-2-pyrimidin-5-ylprop-2-enamide
- ATG-016
- eltanexor
- eltanexorum
- KPT 8602
- KPT-8602
- KPT8602
- ONO-7706
- Definition
- A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1E)-3-amino-3-oxo-2-(pyrimidin-5-yl)prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a second-generation exportin 1 inhibitor that is currently in phase II clinical trial for the treatment of patients with higher relapsed/refractory myelodysplastic neoplasms.
- References
-
- CAS:1642300-52-4
- DrugBank:DB16153
- KEGG:D11499
- PMID:27211268
- PMID:27323910
- PMID:27780859
- PMID:29299164
- PMID:30450161
- PMID:30563936
- PMID:31569391
- PMID:32045477
- PMID:32826328
- PMID:33414399
- PMID:33451349
- PMID:33745946
- PMID:34012430
- PMID:34167562
- PMID:34206543
- PMID:34817872
- PMID:35355406
- PMID:35367710
- PMID:35489384
- PMID:35721113
- PMID:35922861
- PMID:36037515
- PMID:36110547
- PMID:36140245
- PMID:36289662
- PMID:36791564
- PMID:37126200
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from eltanexor
Phenotype where environments contain eltanexor
Phenotype modified by environments containing eltanexor
Human Disease / Model Data
Citations