eltanexor

Term ID

CHEBI:229762

Synonyms

(2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-triazol-1-yl)-2-pyrimidin-5-ylprop-2-enamide
ATG-016
eltanexor
eltanexorum
KPT 8602
KPT-8602
KPT8602
ONO-7706

(all 9)

Definition

A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1E)-3-amino-3-oxo-2-(pyrimidin-5-yl)prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a second-generation exportin 1 inhibitor that is currently in phase II clinical trial for the treatment of patients with higher relapsed/refractory myelodysplastic neoplasms.

References

(all 30)

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes enamide primary carboxamide pyrimidines triazoles

(trifluoromethyl)benzenes enamide primary carboxamide pyrimidines triazoles Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer exportin 1 inhibitor

antineoplastic agent apoptosis inducer exportin 1 inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from eltanexor

Phenotype where environments contain eltanexor

Phenotype modified by environments containing eltanexor

Phenotype affecting eltanexor

Human Disease Model