eltanexor

Term ID

CHEBI:229762

Synonyms

(2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-triazol-1-yl)-2-pyrimidin-5-ylprop-2-enamide
ATG-016
eltanexor
eltanexorum
KPT 8602
KPT-8602
KPT8602
ONO-7706

Definition

A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1E)-3-amino-3-oxo-2-(pyrimidin-5-yl)prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a second-generation exportin 1 inhibitor that is currently in phase II clinical trial for the treatment of patients with higher relapsed/refractory myelodysplastic neoplasms.

References

cas:1642300-52-4
drugbank:DB16153
kegg.drug:D11499
pubmed:27211268
pubmed:27323910
pubmed:27780859
pubmed:29299164
pubmed:30450161
pubmed:30563936
pubmed:31569391
pubmed:32045477
pubmed:32826328
pubmed:33414399
pubmed:33451349
pubmed:33745946
pubmed:34012430
pubmed:34167562
pubmed:34206543
pubmed:34817872
pubmed:35355406
pubmed:35367710
pubmed:35489384
pubmed:35721113
pubmed:35922861
pubmed:36037515
pubmed:36110547
pubmed:36140245
pubmed:36289662
pubmed:36791564
pubmed:37126200

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from eltanexor

Phenotype where environments contain eltanexor

Phenotype modified by environments containing eltanexor

Phenotype affecting eltanexor

Human Disease Model