camonsertib

Term ID

CHEBI:229722

Synonyms

• (3-endo)-3-{6-[(3R)-3-methylmorpholin-4-yl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl}-8-oxabicyclo[3.2.1]octan-3-ol
• camonsertib
• camonsertibum
• RP 3500
• RP-3500
• RP3500

Definition

A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine substituted by 1H-pyrazol-3-yl, (3-endo)-3-hydroxy-8-oxabicyclo[3.2.1]octan-3-yl, and (3R)-3-methylmorpholin-4-yl groups at positions 1, 4 and 6, respectively. It is a highly potent and selective inhibitor of ATR kinase (IC₅₀ = 1 nM).

References

• cas:2417489-10-0
• drugbank:DB18888
• kegg.drug:D12321
• pubmed:34911817
• pubmed:35830811
• pubmed:37277454
• pubmed:38078898
• pubmed:38299539
• pubmed:38378703
• pubmed:38710487
• pubmed:39109923
• pubmed:39422899
• wikipedia.en:Camonsertib

Ontology

ChEBI  ( EBI )