lotilaner

Term ID

CHEBI:229657

Synonyms

3-methyl-N-{2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxamide
5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-2-thiophenecarboxamide
Credelio
lotilaner
lotilanerum
TP 03
TP-03
TP03
Xdemvy

Definition

A member of the class of isoxazoles that is 4,5-dihydro-1,2-oxazole substituted by 4-methyl-5-({2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}carbamoyl)thiophen-2-yl, trifluoromethyl, and 3,4,5-trichlorophenyl groups at positions 3, 5 and 5, respectively (the 5S-stereoisomer). It is a γ-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites, approved for the treatment of Demodex blepharitis.

References

cas:1369852-71-0
drugbank:DB17992
kegg.drug:D11212
pesticides:lotilaner
pubmed:29089066
pubmed:30001727
pubmed:30001745
pubmed:30071885
pubmed:31937370
pubmed:32904661
pubmed:33648556
pubmed:33673848
pubmed:34001200
pubmed:34001223
pubmed:34001224
pubmed:34044853
pubmed:34044864
pubmed:34044877
pubmed:34088338
pubmed:34120646
pubmed:34311929
pubmed:34332895
pubmed:34603770
pubmed:35062996
pubmed:35914297
pubmed:35965392
pubmed:36879347
pubmed:37285925
pubmed:37748769
pubmed:37843754
pubmed:37906372
pubmed:38301215
pubmed:38334465
pubmed:38380217
pubmed:38494618
pubmed:38513948
pubmed:38514290
wikipedia.en:Lotilaner

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from lotilaner

Phenotype where environments contain lotilaner

Phenotype modified by environments containing lotilaner

Phenotype affecting lotilaner

Human Disease Model