Search Ontology:
ChEBI
iptacopan
- Term ID
- CHEBI:229652
- Synonyms
-
- 4-{(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl}benzoic acid
- iptacopan
- iptacopanum
- LNP 023
- LNP-023
- LNP023
- NVP-LNP023
- Definition
- A member of the class of indoles that is 1H-indole substituted by [(2S,4S)-2-(4-carboxyphenyl)-4-ethoxypiperidin-1-yl]methyl, methoxy, and methyl groups at positions 4, 5, and 6, respectively. It is a potent inhibitor of complement factor B (IC50 = 10nM) with potential immunomodulatory activity.
- References
-
- cas:1644670-37-0
- drugbank:DB16200
- kegg.drug:D12251
- pdb-ccd:JGQ
- pmc:PMC10430731
- pubmed:30926668
- pubmed:32073845
- pubmed:33067853
- pubmed:33765419
- pubmed:35561315
- pubmed:35965286
- pubmed:36076550
- pubmed:36217526
- pubmed:37180505
- pubmed:37308298
- pubmed:37441479
- pubmed:37914086
- pubmed:38106570
- pubmed:38182298
- pubmed:38312795
- pubmed:38477987
- pubmed:38517653
- wikipedia.en:Iptacopan
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from iptacopan
Phenotype where environments contain iptacopan
Phenotype modified by environments containing iptacopan
Phenotype affecting iptacopan
Human Disease Model