zavegepant

Term ID

CHEBI:229643

Synonyms

• (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide
• BHV 3500
• BHV-3500
• BHV3500
• BMS 742413
• BMS-742413
• BMS-742413-01
• N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl}-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide
• zavegepant
• zavegepantum

Definition

A member of the class of ureas that is urea in which both amino groups are replaced by 4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidin-1-yl and {(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl}amino groups. It is a calcitonin gene-related peptide receptor antagonist whose hydrochloride salt has been approved by the FDA for the acute treatment of migraine.

References

• cas:1337918-83-8
• drugbank:DB15688
• kegg.drug:D11898
• patent:US2012059017
• pubmed:23632269
• pubmed:33096162
• pubmed:35774914
• pubmed:36189708
• pubmed:36239038
• pubmed:36552072
• pubmed:36804093
• pubmed:37012363
• pubmed:37094060
• pubmed:37227596
• pubmed:37270693
• pubmed:37345774
• pubmed:37363553
• pubmed:37593294
• pubmed:37630989
• pubmed:37723470
• pubmed:37897226
• pubmed:37904462
• pubmed:38311738
• pubmed:38333255
• wikipedia.en:Zavegepant

Ontology

ChEBI  ( EBI )