etrasimod

Term ID

CHEBI:229230

Synonyms

(R)-2-(7-((4-cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
APD 334
APD-334
APD334
etrasimod
etrasimodum

Definition

An organic heterotricyclic compound that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by carboxymethyl and [4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy groups at positions 3R and 7, respectively. It is a potent and functional antagonist of the sphingosine-1-phosphate-1 (S₁P₁) receptor (IC₅₀ = 1.88 nM in CHO cells).

References

cas:1206123-37-6
drugbank:DB14766
hmdb:HMDB0252121
kegg.drug:D10930
pmc:PMC10910369
pmc:PMC10910374
pubmed:25516790
pubmed:30872391
pubmed:31711921
pubmed:33475734
pubmed:33566519
pubmed:35733960
pubmed:36695074
pubmed:36756653
pubmed:36789612
pubmed:36871570
pubmed:36871574
pubmed:37132407
pubmed:37178739
pubmed:37221319
pubmed:37399559
pubmed:37400695
pubmed:37711654
pubmed:37948883
pubmed:37983118
pubmed:38051804
pubmed:38245818
pubmed:38258760
pubmed:38345530
pubmed:38388871
pubmed:38441346
pubmed:38606783
pubmed:38613425
wikipedia.en:Etrasimod

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from etrasimod

Phenotype where environments contain etrasimod

Phenotype modified by environments containing etrasimod

Phenotype affecting etrasimod

Human Disease Model