etrasimod

Term ID

CHEBI:229230

Synonyms

(R)-2-(7-((4-cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
APD 334
APD-334
APD334
etrasimod
etrasimodum

Definition

An organic heterotricyclic compound that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by carboxymethyl and [4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy groups at positions 3R and 7, respectively. It is a potent and functional antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50 = 1.88 nM in CHO cells).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes aromatic ether cyclopentanes monocarboxylic acid organic heterotricyclic compound

(trifluoromethyl)benzenes aromatic ether cyclopentanes monocarboxylic acid organic heterotricyclic compound Show first 5 Terms
has_role: anti-inflammatory drug antibacterial agent immunosuppressive agent sphingosine-1-phosphate receptor 1 antagonist

anti-inflammatory drug antibacterial agent immunosuppressive agent sphingosine-1-phosphate receptor 1 antagonist Show first 5 Terms
inverse is_conjugate_base_of: etrasimod(1-)

etrasimod(1-) Show first 5 Terms
is_conjugate_acid_of: etrasimod(1-)

etrasimod(1-) Show first 5 Terms

Phenotype

Phenotype resulting from etrasimod

Phenotype where environments contain etrasimod

Phenotype modified by environments containing etrasimod

Human Disease / Model Data

Citations