bexagliflozin

Term ID

CHEBI:229225

Synonyms

• (1S)-1,5-anhydro-1-(4-chloro-3-{4-[2-(cyclopropyloxy)ethoxy]benzyl}phenyl)-D-glucitol
• (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol
• (2S,3R,4R,5S,6R)-2-(4-chloro-3-{4-[2-(cyclopropyloxy)ethoxy]benzyl}phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
• (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
• bexagliflozin
• bexagliflozina
• bexagliflozine
• bexagliflozinum
• Brenzavvy
• EGT 1442
• EGT-1442
• EGT0001442
• EGT1442
• THR 1442
• THR-1442
• THR1442

Definition

A C-glycosyl comprising of β-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

References

• cas:1118567-05-7
• drugbank:DB12236
• kegg.drug:D10865
• pubmed:21215314
• pubmed:31101403
• pubmed:31161692
• pubmed:31297965
• pubmed:31432741
• pubmed:31749238
• pubmed:34292100
• pubmed:34975223
• pubmed:35773042
• pubmed:36178197
• pubmed:36867399
• pubmed:36929659
• pubmed:37148170
• pubmed:37409573
• pubmed:37509724
• pubmed:37568270
• pubmed:37651295
• pubmed:37748011
• pubmed:37817422
• pubmed:38151752
• pubmed:38230346
• pubmed:38584148
• wikipedia.en:Bexagliflozin

Ontology

ChEBI  ( EBI )