Search Ontology:
ChEBI
capivasertib
- Term ID
- CHEBI:229222
- Synonyms
-
- (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
- 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
- AZD 5363
- AZD-5363
- AZD5363
- Truqap
- Definition
- An aminopiperidine that is piperidine substituted by 7H-pyrrolo[2,3-d]pyrimidin-4-yl, amino, and [(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]aminocarbonyl groups at positions 1, 4, and 4, respectively. It is a pan-AKT kinase inhibitor used in combination with fulvestrant for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations.
- References
-
- CAS:1143532-39-1
- DrugBank:DB12218
- HMDB:HMDB0248786
- KEGG:D11371
- PDBeChem:0XZ
- PMCID:PMC10431131
- PMID:22294718
- PMID:23394218
- PMID:29084756
- PMID:29242354
- PMID:31836609
- PMID:32205016
- PMID:32359497
- PMID:32359498
- PMID:34837233
- PMID:35398754
- PMID:35490666
- PMID:35688662
- PMID:36508589
- PMID:36519303
- PMID:36572571
- PMID:36714540
- PMID:37093249
- PMID:37224269
- PMID:37256976
- PMID:37311901
- PMID:37328269
- PMID:37449963
- PMID:37543694
- PMID:37574619
- PMID:37596288
- PMID:37726304
- PMID:37803350
- PMID:38096965
- Wikipedia:Capivasertib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 6 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from capivasertib
Phenotype where environments contain capivasertib
Phenotype modified by environments containing capivasertib
Human Disease / Model Data
Citations