Search Ontology:
ChEBI

repotrectinib

Term ID
CHEBI:229220
Synonyms
  • (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one
  • Augtyro
  • repotrectinib
  • repotrectinibum
  • TPX 0005
  • TPX-0005
  • TPX0005
Definition
An azamacrocycle with formula C18H18FN5O2. It is a tyrosine kinase inhibitor (highly potent against ROS1, TRKA-C, and ALK) used for the treatment of locally advanced or metastatic ROS1-positive non-small cell lung cancer.
References
  • cas:1802220-02-5
  • drugbank:DB16826
  • kegg.drug:D11454
  • pdb-ccd:7GI
  • pubmed:30093503
  • pubmed:30188734
  • pubmed:31852910
  • pubmed:32269053
  • pubmed:32278292
  • pubmed:34253025
  • pubmed:34482287
  • pubmed:34625502
  • pubmed:34834176
  • pubmed:35231576
  • pubmed:35334340
  • pubmed:35363931
  • pubmed:36201110
  • pubmed:37262390
  • pubmed:37909502
  • pubmed:37973688
  • pubmed:38047274
  • pubmed:38113652
  • pubmed:38144536
  • pubmed:38197815
  • pubmed:38274094
  • pubmed:38279972
  • pubmed:38322338
  • pubmed:38412271
  • pubmed:38433235
  • wikipedia.en:Repotrectinib
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from repotrectinib
Phenotype where environments contain repotrectinib
Phenotype modified by environments containing repotrectinib
Phenotype affecting repotrectinib
Human Disease Model