nirogacestat

Term ID

CHEBI:229217

Synonyms

• (2S)-2-{[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino}-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)pentanamide
• (S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
• N(2)-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)-L-norvalinamide
• nirogacestat
• nirogacestatum
• PF-03084014
• PF-3084014

Definition

A member of the class of imidazoles that is 1H-imidazole substituted by a 1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl group at position 1 and a {N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-L-norvalyl}amino group at position 4. It is a γ-secretase inhibitor whose hydrobromide salt is indicated for adult patients with progressing desmoid tumours who require systemic treatment.

References

• cas:1290543-63-3
• drugbank:DB12005
• hmdb:HMDB0255626
• kegg.drug:D10960
• pmc:PMC10428426
• pmc:PMC10431067
• pmc:PMC9429688
• pubmed:20363853
• pubmed:22806875
• pubmed:23408105
• pubmed:24573979
• pubmed:24664981
• pubmed:25231399
• pubmed:26202948
• pubmed:26407235
• pubmed:27906684
• pubmed:28350521
• pubmed:28522590
• pubmed:28887726
• pubmed:29232766
• pubmed:29658567
• pubmed:30405889
• pubmed:31211955
• pubmed:32762028
• pubmed:33682447
• pubmed:33791203
• pubmed:34994644
• pubmed:35670122
• pubmed:36068332
• pubmed:36884323
• pubmed:36997640
• pubmed:37325381
• pubmed:37441471
• pubmed:37793461
• pubmed:38237731
• pubmed:38409573
• wikipedia.en:Nirogacestat

Ontology

ChEBI  ( EBI )