Search Ontology:
ChEBI
nirogacestat
- Term ID
- CHEBI:229217
- Synonyms
-
- (2S)-2-{[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino}-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)pentanamide
- (S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
- N(2)-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)-L-norvalinamide
- nirogacestat
- nirogacestatum
- PF-03084014
- PF-3084014
- Definition
- A member of the class of imidazoles that is 1H-imidazole substituted by a 1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl group at position 1 and a {N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-L-norvalyl}amino group at position 4. It is a gamma-secretase inhibitor whose hydrobromide salt is indicated for adult patients with progressing desmoid tumours who require systemic treatment.
- References
-
- CAS:1290543-63-3
- DrugBank:DB12005
- HMDB:HMDB0255626
- KEGG:D10960
- PMCID:PMC10428426
- PMCID:PMC10431067
- PMCID:PMC9429688
- PMID:20363853
- PMID:22806875
- PMID:23408105
- PMID:24573979
- PMID:24664981
- PMID:25231399
- PMID:26202948
- PMID:26407235
- PMID:27906684
- PMID:28350521
- PMID:28522590
- PMID:28887726
- PMID:29232766
- PMID:29658567
- PMID:30405889
- PMID:31211955
- PMID:32762028
- PMID:33682447
- PMID:33791203
- PMID:34994644
- PMID:35670122
- PMID:36068332
- PMID:36884323
- PMID:36997640
- PMID:37325381
- PMID:37441471
- PMID:37793461
- Wikipedia:Nirogacestat
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
- inverse is_conjugate_acid_of
-
- is_conjugate_base_of
-
Show first 5 Terms
Phenotype
Phenotype resulting from nirogacestat
Phenotype where environments contain nirogacestat
Phenotype modified by environments containing nirogacestat
Human Disease / Model Data
Citations