pirtobrutinib

Term ID

CHEBI:229212

Synonyms

5-amino-3-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-pyrazole-4-carboxamide
Jaypirca
LOXO 305
LOXO-305
LY 3527727
LY-3527727
LY3527727
pirtobrutinib
pirtobrutinibum
RXC-005
RXC005

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-fluoro-2-methoxybenzoic acid with the amino group of 5-amino-3-[4-(aminomethyl)phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-pyrazole-4-carboxamide. It is a BTK inhibitor used for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

References

cas:2101700-15-4
chemspider:114875989
drugbank:DB17472
kegg.drug:D12050
pdb-ccd:Y7W
pmc:PMC10428413
pmc:PMC10429556
pmc:PMC10430907
pmc:PMC10431003
pmc:PMC10431162
pubmed:33676628
pubmed:35196427
pubmed:35389384
pubmed:35595730
pubmed:35747462
pubmed:35901282
pubmed:36287227
pubmed:36377973
pubmed:36475521
pubmed:36519322
pubmed:36780414
pubmed:36796019
pubmed:36877244
pubmed:36960657
pubmed:37004673
pubmed:37156004
pubmed:37174062
pubmed:37192437
pubmed:37407001
pubmed:37509309
pubmed:37530617
pubmed:37624619
pubmed:37658026
pubmed:37706363
pubmed:37818564
pubmed:38031799
pubmed:38043933
pubmed:38235739
wikipedia.en:Pirtobrutinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from pirtobrutinib

Phenotype where environments contain pirtobrutinib

Phenotype modified by environments containing pirtobrutinib

Phenotype affecting pirtobrutinib

Human Disease Model