Search Ontology:
ChEBI
zuranolone
- Term ID
- CHEBI:228302
- Synonyms
-
- 1-(3alpha-hydroxy-3beta-methyl-20-oxo-5beta-19-norpregnan-21-yl)-1H-pyrazole-4-carbonitrile
- 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile
- BIIB-125
- BIIB125
- S-812217
- SAGE 217
- SAGE-217
- SAGE217
- SGE 797
- SGE-797
- zuranolone
- zuranolonum
- Zurzuvae
- Definition
- A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.
- References
-
- CAS:1632051-40-1
- DrugBank:DB15490
- KEGG:D11793
- PMCID:PMC10596067
- PMCID:PMC10729607
- PMID:31338688
- PMID:31483961
- PMID:31774968
- PMID:31774969
- PMID:32976892
- PMID:33387701
- PMID:33640861
- PMID:34082218
- PMID:34124495
- PMID:34352138
- PMID:34561029
- PMID:36724109
- PMID:36811520
- PMID:36848317
- PMID:37041352
- PMID:37132201
- PMID:37252829
- PMID:37366077
- PMID:37381161
- PMID:37491938
- PMID:37557991
- PMID:37603679
- PMID:37654113
- PMID:37683318
- PMID:37746458
- PMID:37806320
- PMID:37849543
- PMID:37875578
- PMID:37876133
- PMID:37882942
- PMID:38029628
- PMID:38042632
- PMID:38045802
- PMID:38056137
- Wikipedia:Zuranolone
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from zuranolone
Phenotype where environments contain zuranolone
Phenotype modified by environments containing zuranolone
Human Disease / Model Data
Citations