AZ505

Term ID

CHEBI:228259

Synonyms

• AZ 505
• AZ-505
• N-cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]propanamide
• N-cyclohexyl-N(3)-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide

Definition

A benzoxazine that is 2H-1,4-benzoxazin-3(4H)-one substituted by a hydroxy group at position 5 and a 2-{[2-(cyclohexyl{N-[2-(3,4-dichlorophenyl)ethyl]-β-alanyl}amino)ethyl]amino}ethyl group at position 8. It is a potent and selective inhibitor of SMYD2.

References

• cas:1035227-43-0
• pubmed:21782458
• pubmed:25834495
• pubmed:28588028
• pubmed:28604386
• pubmed:29487338
• pubmed:31754403
• pubmed:32277055
• pubmed:33935284
• pubmed:34143514
• pubmed:34510321
• pubmed:34905676
• pubmed:35455942
• pubmed:35759739
• pubmed:35939202
• pubmed:36046818
• pubmed:37036190
• pubmed:37315132
• pubmed:37524453

Ontology

ChEBI  ( EBI )