alkylating agent

Term ID

CHEBI:22333

Synonyms

Definition

Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: mutagen

mutagen Show first 5 Terms
inverse has_role: 1,2-dimethylhydrazine 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 2,5-bis(aziridin-1-yl)-1,4-benzoquinone 2-aminoacrylic acid 2-chloroethyl methanesulfonate ... Show All 65 Terms

1,2-dimethylhydrazine 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 2,5-bis(aziridin-1-yl)-1,4-benzoquinone 2-aminoacrylic acid 2-chloroethyl methanesulfonate 2-fluoroethyl methanesulfonate 3-bromopyruvic acid 4-hydroperoxycyclophosphamide 4-hydroxycyclophosphamide acrylamide anthramycin apholate aziridine bis(2-chloroethyl) sulfide bis(chloromethyl) ether bromoethane busulfan carmustine chlorambucil chloroacetic acid colibactin cyclophosphamide cyclophosphamide hydrate D-mannitol 1,6-bis(methanesulfonate) dacarbazine diaziquone diazomethane diethyl sulfate dimethyl sulfate dimethyl sulfoxide dimethylmyleran esperamicin A1 estramustine etanidazole ethyl methanesulfonate fotemustine hex-3-yne-2,5-diyl bis(methanesulfonate) hexane-2,5-diyl bis(methanesulfonate) hycanthone mesylate ifosfamide iodoacetic acid L-mannitol 1,6-bis(methanesulfonate) lomustine mechlorethamine melphalan methyl methanesulfonate mitomycin A mitomycin C MTIC N-ethyl-N-nitrosourea N-methyl-N'-nitro-N-nitrosoguanidine N-methyl-N-nitrosourea N-tosyl-L-phenylalanyl chloromethyl ketone nimustine nitrogen mustard pipobroman S-(chloromethyl)glutathione semustine temozolomide tilimycin tomaymycin trabectedin tretamine triaziquone trimethyl phosphite Show first 5 Terms

Phenotype

Phenotype resulting from alkylating agent

Phenotype where environments contain alkylating agent

Phenotype modified by environments containing alkylating agent

Human Disease / Model Data

Citations