Search Ontology:
ChEBI
6-O-methylguanine
- Term ID
- CHEBI:20689
- Synonyms
-
- 2-Amino-6-methoxypurine
- 6-Methoxy-1H-purine-2-amine
- 6-methoxy-7H-purin-2-amine
- 6-Methoxyguanine
- O(6)-methylguanine
- O-(6)-Methylguanine
- Definition
- A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
- References
-
- cas:20535-83-5
- pubmed:1474583
- pubmed:15239064
- pubmed:22185597
- pubmed:2271591
- reaxys:5334996
- wikipedia.en:6-O-Methylguanine
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from 6-O-methylguanine
Phenotype where environments contain 6-O-methylguanine
Phenotype modified by environments containing 6-O-methylguanine
Phenotype affecting 6-O-methylguanine
Human Disease Model