Search Ontology:
ChEBI
poziotinib
- Term ID
- CHEBI:195559
- Synonyms
-
- 1-(4-{[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one
- 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one
- HM 781-36B
- HM-781-36B
- HM781-36B
- NOV 120101
- NOV-1201
- NOV-120101
- NOV120101
- poziotinib
- poziotinibum
- Definition
- A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.
- References
-
- CAS:1092364-38-9
- Chemspider:30687714
- DrugBank:DB12114
- KEGG:D12229
- PMID:21306821
- PMID:25761479
- PMID:29743681
- PMID:29978467
- PMID:30945121
- PMID:31445735
- PMID:32201081
- PMID:32278151
- PMID:32860168
- PMID:33036254
- PMID:33158067
- PMID:33746741
- PMID:33820681
- PMID:33824058
- PMID:33899675
- PMID:34118831
- PMID:34347777
- PMID:34528763
- PMID:34550757
- PMID:34589960
- PMID:34843401
- PMID:34888407
- PMID:35394067
- PMID:35736563
- PMID:35756673
- PMID:35820397
- PMID:36343036
- PMID:36645632
- PMID:36728978
- PMID:36916182
- PMID:36958688
- PMID:36973912
- PMID:37479324
- Wikipedia:Poziotinib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 9 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from poziotinib
Phenotype where environments contain poziotinib
Phenotype modified by environments containing poziotinib
Human Disease Model