poziotinib

Term ID

CHEBI:195559

Synonyms

1-(4-{[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one
1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one
HM 781-36B
HM-781-36B
HM781-36B
NOV 120101
NOV-1201
NOV-120101
NOV120101
poziotinib
poziotinibum

Definition

A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.

References

cas:1092364-38-9
chemspider:30687714
drugbank:DB12114
kegg.drug:D12229
pubmed:21306821
pubmed:25761479
pubmed:29743681
pubmed:29978467
pubmed:30945121
pubmed:31445735
pubmed:32201081
pubmed:32278151
pubmed:32860168
pubmed:33036254
pubmed:33158067
pubmed:33746741
pubmed:33820681
pubmed:33824058
pubmed:33899675
pubmed:34118831
pubmed:34347777
pubmed:34528763
pubmed:34550757
pubmed:34589960
pubmed:34843401
pubmed:34888407
pubmed:35394067
pubmed:35736563
pubmed:35756673
pubmed:35820397
pubmed:36343036
pubmed:36645632
pubmed:36728978
pubmed:36916182
pubmed:36958688
pubmed:36973912
pubmed:37479324
wikipedia.en:Poziotinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from poziotinib

Phenotype where environments contain poziotinib

Phenotype modified by environments containing poziotinib

Phenotype affecting poziotinib

Human Disease Model