Search Ontology:
ChEBI
entrectinib
- Term ID
- CHEBI:195558
- Synonyms
-
- entrectinib
- entrectinibum
- N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide
- N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
- N-[5-[[3,5-bis(fluoranyl)phenyl]methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide
- NMS-E 628
- NMS-E628
- RG 6268
- RG-6268
- RG6268
- Rozlytrek
- RXDX 101
- RXDX-101
- Definition
- A member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours.
- References
-
- cas:1108743-60-7
- chemspider:24808589
- drugbank:DB11986
- hmdb:HMDB0304880
- kegg.drug:D10926
- pdb-ccd:YMX
- pubmed:26633560
- pubmed:27003761
- pubmed:32907817
- pubmed:33290717
- pubmed:34209967
- pubmed:34253025
- pubmed:34536094
- pubmed:34633782
- pubmed:35118559
- pubmed:35447552
- pubmed:35663414
- pubmed:35775007
- pubmed:36101520
- pubmed:36106272
- pubmed:36229359
- pubmed:36340796
- pubmed:36375321
- pubmed:36378538
- pubmed:36419889
- pubmed:36605067
- pubmed:36699581
- pubmed:36703785
- pubmed:36884068
- pubmed:36921521
- pubmed:36924196
- pubmed:37062732
- pubmed:37086377
- pubmed:37122438
- pubmed:37287496
- pubmed:37393426
- pubmed:37492244
- pubmed:37544307
- wikipedia.en:Entrectinib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from entrectinib
Phenotype where environments contain entrectinib
Phenotype modified by environments containing entrectinib
Phenotype affecting entrectinib
Human Disease Model