batimastat

Term ID

CHEBI:195398

Synonyms

(2R,3S)-N(4)-hydroxy-N(1)-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
(2R,3S)-N(4)-hydroxy-N(1)-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-2-(2-methylpropyl)-3-[(thiophen-2-ylsulfanyl)methyl]butanediamide
4-(N-hydroxyamino)-2R-isobutyl-3S-(thiopen-2-ylthiomethyl)-succinyl-L-phenylalanine-N-methylamide
batimastat
batimastatum
BB 94
BB-94
BB94

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.

References

cas:130370-60-4
chemspider:4515033
drugbank:DB03880
kegg.drug:D03061
lincs.smallmolecule:LSM-6276
metacyc.compound:CPD-21519
pdb-ccd:BAT
pubmed:10100701
pubmed:10416010
pubmed:10566008
pubmed:10628317
pubmed:11129784
pubmed:11435723
pubmed:11575928
pubmed:11718018
pubmed:12172929
pubmed:14741217
pubmed:15206921
pubmed:22684055
pubmed:24819550
pubmed:26443597
pubmed:26546696
pubmed:26559179
pubmed:28417261
pubmed:32048249
pubmed:32397419
pubmed:32411205
pubmed:33330030
pubmed:34055088
pubmed:34060428
pubmed:36001659
pubmed:36482856
pubmed:36825288
pubmed:37302822
pubmed:7577999
pubmed:7627972
pubmed:8062271
pubmed:8347186
pubmed:8610113
pubmed:8665519
pubmed:8913271
pubmed:8913840
pubmed:9816289
pubmed:9882797
pubmed:9932102
wikipedia.en:Batimastat

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from batimastat

Phenotype where environments contain batimastat

Phenotype modified by environments containing batimastat

Phenotype affecting batimastat

Human Disease Model