beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc

Term ID

CHEBI:194543

Synonyms

• 6-deoxy-alpha-L-galactopyranosyl-(1->3)-[6-deoxy-alpha-L-galactopyranosyl-(1->4)-[beta-D-galactopyranosyl-(1->3)]-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)]-2-acetamido-2-deoxy-D-glucopyranose
• beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc
• beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine
• Galbeta1-3(Fucalpha1-4)GlcNAcbeta1-3Galbeta1-4(Fucalpha1-3)GlcNAc
• Le(a)Le(x)
• Le(a)Le(x) hexasaccharide

Definition

A branched amino hexasaccharide, denoted Le^aLe^x, consisting of a tetrasaccharide backbone of β-D-galactosyl, N-acetyl-β-D-glucosaminyl, β-D-galactosyl and D-glucosamine residues linked glycosidically in a (1→3), (1→3), (1→4) sequence, the N-acetyl-β-D-glucosaminyl and reducing-end N-acetyl-D-glucosamine residues of which also carry α-L-fucosyl residues via (1→4) and (1→3) glycosidic linkages respectively. The mouse anti-Le^a monoclonal antibody SPM 522 has been reported to bind to Le^aLe^x better than to Le^a alone.

References

• pubmed:35078031

Ontology

ChEBI  ( EBI )